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November 7, 2009 1:38 PM PST

How much would you pay to see your future?

by Elizabeth Armstrong Moore
  • 29 comments

My dad used to say technology is advancing so quickly that, by the time a product reaches market, it is already obsolete. Moreover, if you wait just a little longer, you can pay a lot less. The sequencing of the human genome takes the advancement of technology, and its fast reduction in cost, to an entirely new level.

Whole-genome sequencing could be affordable and accurate enough to perform on every newborn with a simple heel-prick blood test in a matter of years.

(Credit: Elizabeth Armstrong Moore/CNET)

The Human Genome Project, which officially completed the mind-boggling achievement of sequencing Jim Watson's genome in 2006, carried the equally mind-boggling price tag of $3 billion. If I may be so bold as to use that word thrice in one paragraph, even more mind-boggling is that a company called Complete Genomics has just sequenced three human genomes for $4,400 in materials, with an error rate of less than one base in 100,000.

DNA sequencing technology, which could help us detect genetic predispositions to illnesses, customize treatments accordingly, lead to the development of new energy sources, etc., is currently being used to either do long reads of hundreds of bases on genomes that have yet to be sequenced (see the news this week on the full sequencing of the domestic horse genome), or shorter reads that only align with a genome we have already sequenced (ours, for example).

In a paper published in the journal Science on Thursday, Complete Genomics shares the methods it used, which John Timmer at Ars Technica describes as "clever variants of well known molecular biology techniques to read massive amounts of DNA fragments that are, in total, about 65 bases long."

Moreover, Complete Genomics used more common--read more affordable--materials. For a detailed explanation of how this was done, check out the paper in Science, or Timmer's illustrated translation for Ars Technica.

Complete Genomics is not the lone warrior in this field. As CNET's Stephen Shankland reported in October, IBM Research has jumped into the game, and hopes to reduce the cost of genetic testing to as little as $100 per person. And then there's genomic technology manufacturer Illumina, and 454 Life Sciences. The list grows.

At this rate of advancement, it has been widely reported that the technology for whole-genome sequencing could be affordable and accurate enough to perform on every newborn with a simple heel-prick blood test in a matter of years. This makes a lot of people uneasy for several reasons, not the least of which is privacy.

"Bad things can be done with the genome," Dr. Jay Flatley of Illumina tells Times Online. "It could predict something about someone--and you could potentially hand information to their employer or their insurance company. People have to recognize that this horse is out of the barn, and that your genome probably can't be protected, because everywhere you go you leave your genome behind."

I have to wonder which is more unnerving to most people--that others will be able to access our genomic fingerprints, or that our bodies are able to be so accurately read at all. The secrets currently locked within us carry a certain mystique, and once unlocked could be put to uses that are possibly beyond our control. Whether this makes the human body more or less magical is debatable, but this much is not: The horse is out of the barn.

Originally posted at Health Tech
Elizabeth Armstrong Moore is a freelance journalist based in Portland, Ore. She has contributed to Wired magazine, The Christian Science Monitor, and public radio. Her semi-obscure hobbies include unicycling, slacklining, hula-hooping, scuba diving, billiards, Sudoku, Magic the Gathering, and classical piano. She is a member of the CNET Blog Network and is not an employee of CNET.
June 25, 2009 12:01 AM PDT

IEEE awards prizes for tech that benefits humanity

by Elinor Mills
  • 1 comment

I always like to write about technology that wasn't designed to serve a market (meaning, consumers who will pay) per se, but which was designed with a humanitarian need in mind.

Students from the B.V. Bhoomaraddi College of Engineering and Technology in India won an award for developing electronic aids for handicapped children.

(Credit: IEEE)

On Thursday in Los Angeles the IEEE (formerly the acronym for Institute of Electrical and Electronics Engineers) is holding its first IEEE Presidents' Change the World Competition award ceremony.

The world's largest technical professional society is granting prize money to students from around the world who develop "unique solutions to real-world problems using engineering, science, computing and leadership skills to benefit their community and/or humanity as a whole."

The IEEE Student Humanitarian Supreme Prize of $10,000 will be awarded to two Stanford students for developing what they called the NanoLab, "a hand-held diagnostic laboratory capable of quantitative multiplex protein detection in a very simple to use, wash-free assay," which would be particularly useful in developing countries.

A team of 19 students from B.V. Bhoomaraddi College of Engineering and Technology in India are receiving a $5,000 prize for developing electronic games, devices, and toys designed to stimulate physically and mentally handicapped children and encourage exercises.

A bicycle-powered grain crusher, targeting developing countries without easy access to electricity for motors, won five students from Rowan University in New Jersey a $2,500 prize.

Smaller prizes were awarded for other projects, including one involving robots in agriculture, several related to distributing electricity in rural and small communities, and electronic health care for the under-privileged.

Every fall the Tech Museum in San Jose, Calif., grants awards for technology innovation that benefits humanity.

Corrected at 8:50 a.m. PDT: The award ceremony is Thursday.

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November 12, 2008 4:00 AM PST

Tech Museum honors tech that benefits humanity

by Elinor Mills
  • 3 comments

A Huichol woman does bead work while her son finishes his homework by the light of a Portable Light device.

(Credit: KVA MATx)

Living in San Francisco, we take technology for granted. We have YouTube and iPhones and online maps. We get annoyed when a Web page downloads too slow or our phone call drops.

Then there are the millions of people who don't live in developed countries, who go without the Web and even electricity and light for most if not all of their day. For them, things like Windows 7 and Facebook are irrelevant, but they still dominate the technology landscape.

There are some innovators designing technology for use by the rest of the world, companies and nonprofits that are applying technology to help people improve their lives. The Tech Museum in San Jose, Calif., offers its Tech Museum of Innovation awards to projects that apply technology to benefit humanity.

Established in 2001, the awards recognize 25 laureates in the categories of education, equality, environment, economic development, and health. One laureate in each category will receive a $50,000 cash prize. The winners will be announced at a ceremony on Wednesday night at which professor Muhammad Yunus, a pioneer of microcredit and founder of Grameen Bank, will speak.

CNET News talked to 5 of the 25 laureates and got a glimpse of some of the technologies that are doing things like preventing spread of disease from reuse of infected needles, monitoring the air around farms for dangerous pesticides, turning the PC into a 3D design tool, and bringing light to dark places on the map.

Textiles that illuminate
Sheila Kennedy was traveling in Mexico studying solar applications in 2002 when she saw a group of native Huichol women cooking by the side of the road because they had insufficient light to cook in their homes and she had an epiphany. She saw a practical use for flexible solar panel technology and solid-state lighting that her architectural design firm in Boston, Kennedy & Violich Architecture, was experimenting with.

A Huichol woman wears a Portable Light device integrated into textiles that can be worn.

(Credit: KVA MATx)

She formed a nonprofit, the Portable Light Project, and began a collaboration with renewable-energy think tank The Rocky Mountain Institute to launch a pilot project with the Huichol in the Sierra Madre mountains in north central Mexico. The project provides a way for indigenous communities to have bright light inside their homes at night, recharge the power with the sun during the day, and charge cell phones and medical devices as well.

Participants in the project receive solar kits that they integrate into their textiles to suit their needs. The kit includes one or two thin-film 10-by-4-inch photovoltaic panels, an LED, and a control pouch with digital drive electronics and a small lithium-ion rechargeable battery. The self-contained renewable energy source is lightweight, easy to integrate into existing materials, and is customizable.

"It's an elegant textile surface that can be folded or formed," Kennedy said. "It's got great optics, with parabolic reflector shapes made from folded textiles which bounce reflected light from solid-state lighting sources."

It takes about 2.5 hours to fully charge a battery and it offers about 10 hours of light at about 100 lumens using only 1 watt. By contrast, a 100-watt, 120-volt bulb produces 17.5 lumens per watt.

Projects are under way for Nicaragua, and the Brazilian and Venezuelan Amazonias. The group also is working to use ultraviolet-emitting LEDs for a water purification capacity using portable light. And in another project, Portable Light has created a hospital blanket using the nanotechnology for medical workers in South Africa to send home with patients with HIV who are bedridden.

"Sunlight kills bacteria that causes tuberculosis, but many of the patients sit at home in the dark," Kennedy said. With the blanket "they can wrap themselves in the blanket, produce electricity, store it, and then provide power for their family and caretakers around the clock."

Syringes that save lives
Brit Marc Koska was living in the American Virgin Islands in the early 1980s, "with a first-class honors in beach bum," when he saw a newspaper article about how the reuse of syringes in developing countries would make them a major transmission route for HIV infections. He decided to work on tackling the problem and eventually developed the K1 Syringe, the world's first syringe that automatically disables after it is used once.

Marc Koska talks to some Indian boys at risk of getting infected from needle sticks while digging through a dump.

(Credit: Star Syringe )

A ring in the barrel of the syringe locks the plunger in place once it is fully depressed so it can't be used again. The syringes sell for about 5 cents, he said.

Twenty-four years later, and 17 years of no sales, Koska, now 47, heads up Star Syringe with 14 licensees around the world producing more than 2 million K1 syringes a day. It is estimated that his syringe has saved more than 5 million lives.

"The manufacturing process was the lowest hanging fruit," he said. "It was critical to make a design that would easily retrofit onto existing machinery."

Currently, half of the injections given in the developing world are unsafe (the rate rises to 65 percent in India) and the World Health Organization reports that reused syringes are believed to be responsible for 1.3 million deaths a year, mostly malaria.

"A mother taking her baby to a doctor for any routine vaccination could leave with hepatitis or HIV" because the doctor reused an unclean needle, Koska said. "It happens for many reasons, including poor distribution of supplies, but informing the public of the issue will be critical in tackling this global problem."

His next project, SafePoint Trust, does just that.

Monitoring the air for carcinogens
For decades, people living near farms in California's Central Valley complained that they got headaches, fainted, or got sick after pesticides were sprayed on nearby crops.

Jorge Alvarado operates the Drift Catcher while PANNA Scientist Karl Tupper stands by.

(Credit: Sara Bjorkqvist)

Pesticide exposure has been linked to increased incidences of certain types of cancer, birth defects, Parkinson's disease, asthma, and other illness. According to a 2007 study, autism rates for children born to California women exposed to certain pesticides during their first trimester of pregnancy were six times greater than normal. Still, communities have been told that spraying is safe. Without any proof otherwise it seemed there was nothing that could be done.

That is until Dr. Susan Kegley developed the Drift Catcher for the San Francisco-based Pesticide Action Network North America (PANNA).

The device is an easy-to-use, affordable air monitoring system that measures the concentrations of hazardous pesticides in the air. A vacuum pump pulls air through two glass sampling tubes. The tubes contain a resin which traps pesticides as the air moves through. Tubes are typically changed every 24 hours and samples must remain cold until they are analyzed by PANNA scientists in the laboratory.

"The device enables communities to scientifically document when levels of pesticides in the air near their homes and playgrounds exceed what the Environmental Protection Agency says are safe," said Kathryn Gilje, executive director of PANNA.

"Now, we can amass enough data to make a change in policy to make (pesticide drift) illegal," Kegley said. "Air sampling has been around for a long time, but now you can do it cheaply enough so someone can set it up in their back yard" and start measuring when they see the tractors spraying pesticides.

The Pesticide Action Network has about 50 of the devices out in the field. The Drift Catcher has been used by community activists in California, Minnesota, Florida, Washington, Indiana, Maine, and Hawaii.

Evidence from the Drift Catcher devices likely played a role in keeping the maker of the herbicide molinate on track for voluntarily withdrawing the chemical from the market. It also played a role in the EPA requiring larger buffer zones around fumigated fields and requiring farmers to provide notice to the community about what pesticide they are using, Kegley said.

The group also is pushing the U.S. Department of Agriculture to help farmers move away from using toxic chemicals and adopt safer alternatives.

Renewable light by the hour
Andy Schroeter learned first-hand about the difficulties people in developing countries have getting affordable access to light sources when he was working in Laos and Vietnam for a German development organization beginning in 1995. Not only are 44 percent of the population in Laos off the electricity grid, but paying for kerosene to light lamps winds up being one of the highest costs for a household.

Men in Laos get trained on how to operate solar panels that recharge lanterns rented to villagers. Note the solar panels on top of their hats.

(Credit: Sunlabob Renewable Energy)

So Schroeter created the Sunlabob Renewable Energy company to help solve that problem.

Based in Laos, the company rents large central solar charging stations to village businesses which, in turn, rent out rechargeable exchangeable solar lanterns to households. The lanterns can be used to charge mobile phones, small TVs, radios, and laptops.

"We are creating a sustainable model for a village," Schroeter said. "In rural areas in developing countries people don't have the cash to pay for initial investments for the hardware."

Each lantern has an integrated microprocessor that alerts a user when the power is low and collects data that can be used for carbon offset purposes.

The lantern light lasts for about 10 hours and costs as little as 40 cents, Schroeter said, adding that light lasts as long as three days for families in Laos.

In addition to Laos, Sunlabob is providing services to villages or has franchises in Uganda, Cambodia, Singapore, and Tanzania and will soon be operating in Afghanistan.

3D for the masses
When Daniel Ratai was 13 he wanted to design cars. But he found that using pencil and paper was too limiting and there were no computer programs that would allow him to do exactly what he wanted.

Research institutes are using Leonar3Do for pharmaceutical research.

(Credit: 3D for All)

"In kindergarten I tried to draw 3D designs on paper. I dreamed about drawing into the space," says Ratai, a Hungarian. "I could imagine the car in my head and see it on the top of a table."

So, when he was 18 he started working on a system that would let him do as he wanted. His firm, 3D For All, developed the Leonar3Do console and specialized software that works with any PC.

Sensors attach to the monitor and the user wears a pair of 3D goggles and draws with a 3D pen, creating whatever their mind can imagine in the space in front of the monitor.

The system can be used for creating virtual environments, buildings, anything. A research group is using it to control 3D microscopes for molecule docking, Ratai said.

Prototypes are currently being tested and initial systems should be available to the public for between $1,000 and $1,200 next year, he said.

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