August 20, 2009 4:00 AM PDT

Micro injections: Score 1 for needle-phobes

by Elizabeth Armstrong Moore
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I'll admit that I've never understood the fear of needles. Ever since I was little, I thought it was cool that something could go so deep with only a tiny little sting. My mom told me to think of Strawberry Shortcake, and I'd push out my little chin, watch the needle go in, and cheer.

Yet several people in my life, whose anonymity I'll do them the favor of preserving, practically faint at the mere sight of a needle. Score one for the afflicted, because a new "microneedle patch" supposedly takes the sting out of shots.

An array of "microneedles" could administer drugs without so much as a sting.

(Credit: Gary Meek)

"It's our goal to get rid of the need for hypodermic needles in many cases and replace them with a patch that can be painlessly and simply applied by a patient," says Mark Prausnitz of the Georgia Institute of Technology, who announced this promising alternative at the 238th National Meeting of the American Chemical Society in Washington this week. "If you can move to something that's as easy to apply as a Band-Aid, you've now opened the door for people to self-administer their medicine without special training."

The microneedle relies on advances in microfabricating extremely tiny objects. Each needle in this patch is in fact only a few hundred microns long, or about the width of a few strands of human hair. Prausnitz's team, in collaboration with Emory University, administered flu vaccines to mice via both conventional injections and microneedle patches. The resulting antibody levels looked identical; on closer inspection, it turns out that the microneedle patch resulted in an even better immune result.

One potential use for this patch is treating macular degeneration, the leading cause of blindness in the U.S. Drugs that treat macular degeneration must be injected directly into the eyeball every month; while I harbor no fear of needles whatsoever, I can think of plenty of ways I'd rather spend my time. And though the microneedle patch would also have to be placed on the eye, it seems like a far less invasive alternative.

The first clinical trial on humans is expected to begin in 2010.

Elizabeth Armstrong Moore is a freelance journalist based in Portland, Ore. She has contributed to Wired magazine, The Christian Science Monitor, and public radio. Her semi-obscure hobbies include unicycling, slacklining, hula-hooping, scuba diving, billiards, Sudoku, Magic the Gathering, and classical piano. She is a member of the CNET Blog Network and is not an employee of CNET.
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by badkhanjo August 20, 2009 6:47 AM PDT
As someone that has lived his entire life with a very powerful phobia of needles I can assure you that the fear ( speaking for myself ) has nothing to do with any perceived pain. In my mind, there is something horribly invasive and somehow just wrong, un-natural ( words fail me here ) about sticking a long hypo into human flesh. And you're right for many the mere sight of a needle ( and they always show them being used on TV news programs...ughh! ) can trigger a strong reaction. The above photo of the patch has not done that to me yet. Hope springs eternal.
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by tdlucas August 20, 2009 9:51 AM PDT
Yes! I can finally get a saeasonal flu shot now. ?
by Dalkorian August 20, 2009 10:10 AM PDT
I guess my phobia isn't as strong as yours. The sight of needles doesn't bother me in the slightest, it's just an inanimate object to me.

It's seeing a needle being used that I can't stand. Interestingly, expressions such as "wrong" and "un-natural" come quickly to mine (as does "rape"). I have always looked away when the needle starts to go in, both in real life and in TV as well. I just can't watch it.
by Vegaman_Dan August 20, 2009 8:48 AM PDT
Doctor Leonard McCoy would approve of this method. We're not far from a Hypospray with this technology.
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by JustinScientist August 20, 2009 9:35 AM PDT
If we don't need to go deep through the skin to inject the chemical we're injecting, why do we go so deep with a normal needle? I have a mild tension towards needles, and it feels like many people's issues would be resolved if they didn't have to get injected so deeply.
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by gsmiller88 August 20, 2009 11:16 AM PDT
I would say they have to go so deep because of the amount of medicine that's being injected. With these patches, the medicine is absorbed over a period of probably hours or days, but with a regular needle you're getting all of the medicine in one whack.
by ikramerica--2008 August 20, 2009 1:02 PM PDT
I'd say it's that, plus "that's the way it's always been done" is a very strong force in medicine, for better or worse.
by Vegaman_Dan August 20, 2009 1:07 PM PDT
The larger needle has a much larger volume of material to get injected and needs to connect to a vein. The method described instead uses multiple smaller ones which each has a small volume and is much more easily absorbed at the outer layers with smaller blood vessels/capilliaries. A large needle would end up only pooling the injection into those layers without proper absorbtion.
by brainstuff August 21, 2009 5:57 AM PDT
I like this! .... but I would that the developpers use me as a "beta-tester" ... if this item can stop my EXTREME "needle-phobie", only then,, the item will be use-ful. (I have support in my life only ONE needle ... after 7 h of combats with my mother who was a doctor ...... she has used a verry fine needle to apply a vaccin)

hjspub@barainstuff.com
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by brainstuff August 21, 2009 10:44 AM PDT
correct address: hjspub@brainstuff.com
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