We've given up: The endless proliferation of remotes in our household is out of control. We've tinkered with so-called universal models, but they either don't seem to work or, more likely, we're just too "challenged" to figure them out.
The only solution, at least in the near term, may be a reduction in their rabbit-like numbers by consolidating them in sub-categories. To wit: The new "Universal Gamer" may not take care of everything in the house, but it at least claims to work with the Xbox 360 and PlayStation 2 (if not the Wii), as well as six other devices including HDTV, TiVo and cable, according to Electronic House.
It's not ideal, but we'll take what we can get; our remotes are starting to talk about organizing a union. Of course, all this is moot if you're controlling your console through brainwaves alone.