The redesign makes the site look a little slicker, and certainly accentuates Dropio's "easy to use" mantra. It's also clearly a consumer-oriented product now--in comparison, the old design looks like a back-end content management system. That's good, because the company hopes to appeal to Luddites as well as techies. (For a business model, Dropio offers premium accounts that get rid of the 100MB free account storage limit.)
Feature-wise, it's pretty much the same, but Dropio's team has said that it's "about a thousand times more customizable and useful" thanks to a newly reorganized dashboard. They also say that the speed of the site should also be a notch higher.