compound

3D computer model helps screen millions of chemo drugs

Researchers have long used still images of proteins known to be related to recurring cancers in an attempt to understand exactly why these proteins make some chemotherapies fail.

Now, biochemists at Southern Methodist University are using a 3D computer model of the human protein P-glycoprotein -- believed to play a pivotal role in the failure of chemotherapy in many recurring cancers -- to screen more than 8 million potential drug compounds in the hunt for one that will help stop this failure.

"This has been a good proof-of-principle," biochemist John G. Wise said in a school news release. &… Read more

The 404 811: Where we pick a new Mayor of Cave Street (podcast)

The Internet already has jokes about the news of Osama's death and last night's subsequent broadcast, and someone already created a Google Maps location for Osama's compound on "Cave Street" with four pages of hilarious reviews. We also have a story a programmer living in Abbottabad, Pakistan that accidentally livetweeted the death of bin Laden, as well as more random topics like Tom Tom's privacy flub, the bacteria content of your steering wheel, and a Finger-nose stylus for your touch screen devices!

The 404 Digest for Episode 811

Osama's compound pops up on Google Maps, with reviews. Programmer unknowningly liveblogs the events in Pakistan. TomTom supplies driving data to police to set speed traps. Your car steering wheel is dirtier than a public toilet seat (good thing I drive with my knees). Eyes Wide Shut-esque finger-Nose stylus for touch screens.

Congratulations to @Blood_Nut and @Steamypeas for their winning entries in our #Gunnar404 contest. Direct message us @The404 to claim your Gunnar Optiks Performance Eyewear!

Episode 811 Subscribe in iTunes (audio) | Subscribe in iTunes (video) | Subscribe in RSS Audio | Subscribe in RSS Video… Read more

Mobile iPod speaker desk: Take it with you

Now, here's a simple design that's really ingenious. The Compound Body 2 is one of many handiworks from Korean designer Yu Kwang Soo and his speaker furniture collection. This particular piece hides a stereo with custom cutouts for the boomboxes, control knobs, and an iPod dock within a wooden desk.

In addition, the table can be folded to reduce its footprint, while the entire concoction is collapsible for transportation. For this matter, a shoulder strip and handrails are included for mobility.

Apparently, some of the inspiring designer's offerings have been showcased at the recent Seoul Living Design … Read more

Bank bot keeps an eye on your money

Sure, there are fancy robots out there that can spy, fly and even take your tempurature, but do they care about your financial well-being?

Unlike a lot of those other hot-shot bots, the "Robot Bank" isn't here to show off--it just goes about its business, encouraging you to save for the future and diligently toting up every penny you drop in. Don't try to cheat, either: It recognizes withdrawals and will make disapproving noises if you try to sneak a few bucks.