Science and research

3D computer model helps screen millions of chemo drugs

Researchers have long used still images of proteins known to be related to recurring cancers in an attempt to understand exactly why these proteins make some chemotherapies fail.

Now, biochemists at Southern Methodist University are using a 3D computer model of the human protein P-glycoprotein -- believed to play a pivotal role in the failure of chemotherapy in many recurring cancers -- to screen more than 8 million potential drug compounds in the hunt for one that will help stop this failure.

"This has been a good proof-of-principle," biochemist John G. Wise said in a school news release. &… Read more

Nick Bilton gave me a case of the (e-book) blues

The fog has lifted making for a gorgeous day in San Francisco. Thank you Nick Bilton for screwing it all up for me.

Actually, Bilton wrote a terrific piece today in The New York Times today, recounting his state of mind after frequenting a clutch of bookstores during a trip to Manhattan. It also left me feeling low as I nodded in agreement as he recounted the bittersweet price Kindle (and other digital) converts are paying perhaps without realizing the cost.

So I went inside, pushing open the large wooden door, which creaked like a prop borrowed from a horror-movie … Read more

Internet usage patterns may signal depression, study finds

The amount and type of online activity Internet users exhibit may be indicators of depression, findings a group of researchers hopes will lead to software tools to help identify depressive behavior.

People who showed symptoms of depression tended to use the Internet differently than those who didn't show signs of depression, researchers said in a New York Times opinion piece today. Some of that behavior included obsessively checking e-mail, watching lots of videos, and switching frequently among multiple apps, according to a new study by researchers from the Missouri University of Science and Technology.

The researchers asked 216 college … Read more

MIT video tech could be a remote pulsometer -- or a lie detector

In the Fox TV show "Lie to Me," Dr. Cal Lightman was able to tell whether someone was lying by observing what he called "micro expressions" on their faces. The twitch of an eye, the quickening of a pulse, the beads of sweat on a brow -- he looked for clues too subtle for most of us to catch.

Now, researchers out of MIT are developing a video technology they call Eulerian Video Magnification that could do that and more -- by amplifying the motion in a standard video sequence to detect information not visible to … Read more

How to watch online as a huge asteroid flies by Earth today

A ginormous space asteroid about the size of a full city block is heading our way today, and you can secure a front row seat online to watch as it zips past the Earth later.

The asteroid, known to astronomers as 2012 LZ1, is expected to pass within 14 lunar distances of Earth, or roughly 3.35 million miles. In space terms, that's a relatively close call, though still far enough way so as not to ruin your summer plans.

The Slooh online skywatching service, which has a telescope set up on the Canary Islands, plans to stream the … Read more

New flu detection test can be carried in a first aid kit

After the H1N1 "swine flu" virus jumped from pigs to human in 2009, more than 18,000 people died and the Centers for Disease Control and Prevention called it the first global pandemic in more than 40 years.

Today, biomedical engineers out of Brown University and Memorial Hospital in Rhode Island hope that their prototype flu detector biochip will help contain the next major flu outbreak by enabling the quickest, most accurate, and most affordable diagnosis possible.

The team's assay, which they call SMART (short for A Simple Method for Amplifying RNA Targets), consists of a series … Read more

How the White House is aiming the X Prize model at big problems

On October 4, 2004, the idea of incentive prizes hit the mainstream when Burt Rutan and his team at Scaled Composites launched SpaceShip One into orbit for the second time and won the $10 million Ansari X Prize.

Since then, prizes like that have become more and more common, and though the X Prizes are still the gold standard, there are now similar competitions from medical research to science to business, and beyond.

Not long ago, however, the U.S. government got into the business (PDF) of using competitions like these to come up with new ways to solve existing … Read more

Bill Gates' magical bracelets to monitor kids' attentiveness

Science, rationality's clever henchman, sometimes has strange ideas.

One that has entered the firmament is a "Galvanic" bracelet that uses physiological signs to measure just how engaged a child is in school.

I am grateful to the Washington Post for revealing that such bracelets are now subject to a grant from the Bill & Melinda Gates Foundation.

I hadn't been aware that one's skin could be such a giveaway of my mental state. Sometimes, it's just dry because I forget to lather myself in lovely Philosophy body lotion. (Try it. It smells wonderful.)

And … Read more

Building a better bladder for an H20-thirsty world

How do you design a water bottle for the end of the world?

That's the question that was put to the team at Japanese design-engineering firm Takram, which has worked with, among others, Toshiba, NTT Docomo, and Toyota. Their novel response? Forget about the bottle and create artificial organs that could be implanted in humans to make their bodies more efficiently use what water is available should resources become scarce.… Read more

DASH robot learns cockroach escape trick

Cockroaches are way faster than you and me. Relative to their body weight, they can flee at the equivalent of hundreds of miles per hour and are gone long before your newspaper hits the floor.

But researchers from the University of California at Berkeley recently described how cockroaches can also run toward a ledge and then flip around to its underside in the blink of an eye, effectively disappearing from predators. Now they're working on robots that can do the same. … Read more