Pain has long been thought to be at least somewhat subjective, making it difficult to measure consistently from one person to the next. But in a new study out of the University of Colorado at Boulder, healthy volunteers subjected to a dose of intense heat all experienced a consistent pattern of neurological activity that scientists captured on function MRI, which tracks blood flow through the brain.

While this doesn't mean that people experience pain in exactly the same way, the findings -- published today in the New England Journal of Medicine -- suggest that there may be a better … Read more

Studying the brain can be a tricky business.

The interesting stuff, such as neurons and how they communicate, is obscured by things like fatty tissue. Usually, scientists just cut it up into paper-thin slices to study, like with Einstein's brain, but a team of scientists at Stanford University, led by Karl Deisseroth and Kwanghun Chung, have found what the director of the National Institute of Mental Health Thomas Insel is calling "one of the most important advances for doing neuroanatomy in decades."

The new technique lets researchers leave the brain intact, which puts an end to the damage that slicing can cause. It involves infusing the brain with acrylamide, which binds the proteins; once heated, it polymerizes, preserving the important molecules. Then, the brain is rinsed with sodium dodecyl sulfate (SDS) detergent, which strips the fatty lipids, leaving intact the proteins that the researchers wish to study. … Read more

Researchers who shined a laser light in a certain region of the brain -- stimulating the area associated with decision-making and impulse control -- were able to zap what they call "cocaine seeking" behaviors in addicts.

And while their work was on rats, their hope is that a similar technique called transcranial magnetic stimulation (TMS, currently used to improve symptoms of depression) will work on humans as well.… Read more

Researchers have been exploring breath tests for all sorts of uses -- from sniffing out everything from lung cancer to heart disease to diabetes. But testing for obesity? Could that really be possible?

According to a new study in the April issue of the Journal of Clinical Endocrinology & Metabolism, the bacterial overgrowth that can be caught by a standard breath test may also reveal one's body fat percentage.

Apparently when one's microbiome (the complex infrastructure of good and bad bacteria that live in and on us) gets out of balance, with the bad bacteria outperforming the good, … Read more

Turning to robots for speech and physical therapy may not be everyone's idea of high-quality, personalized health care. But for stroke patients -- particularly those in rural, isolated areas -- therapists can be difficult and expensive to come by, and rehabilitation can be elusive.

So a speech language pathologist at the University of Massachusetts Amherst is studying the interactions of stroke patients with the uBot-5, a child-size humanoid robot with arms and a computer screen through which therapists can interact with people. And for at least one stroke patient, the bot appears to be doing a stand-up job.… Read more

Our body tissue, not to mention diseases, each have their own unique "fingerprint," which can in turn be examined to diagnose various health issues at very early stages.

Now, researchers at Case Western Reserve University in Cleveland say that after a decade of work they've developed a new MRI (magnetic resonance imagining) technique that can scan for those diseases very quickly. In just 12 seconds, for instance, it may be possible to differentiate white from gray matter in cerebrospinal fluid in the brain; in a matter of minutes, a full-body scan would provide far more data, making diagnostics considerably easier and less expensive than today's scans.… Read more

Some 2 billion people around the world are affected by parasitic worms. Researchers trying to help them may soon use a simple iPhone hack.

The Toronto General Hospital's Isaac Bogoch and colleagues found that "mobile phone microscopy" has a sensitivity of about 70 percent for detecting the eggs of parasitic worms, also known as helminths.

Reporting in The American Journal of Tropical Medicine and Hygiene (PDF), the researchers described attaching a ball lens costing less than $15 to the camera of an iPhone 4S with double-sided tape.

They pierced a small hole in the tape and placed the ball lens against the hole.

Next, smear slides of stool samples from children in Tanzania were held up against the tape while a flashlight illuminated the slides.

The camera snapped images of the samples and the results were checked for the presence of eggs. The camera could resolve eggs as small as 40-60 micrometers in diameter. … Read more

An electrical engineer at Stanford has led the effort to develop an endoscope that is not only as thin as a human hair but also boasts a resolution four times better than existing ultrathin models. The "micro-endoscope" could lead to far less invasive bio-imaging, making it easier and safer to peer inside living organs and tissue to, say, study the brain and detect cancer.

The researchers, led by Joseph Kahn at the Stanford School of Engineering, report in the journal Optics Express and the Optical Society of America's Spotlight in Optics that the prototype can resolve objects … Read more

What if you could "street view" the human body, navigating its interactive components all the way down to a metabolic level? An international group of scientists is working on that right now with a map of the human metabolism, which they call Recon 2.

Metabolism plays a key role in many diseases, and while scientists have already managed to reconstruct several models of it, each "represents only a subset of our knowledge" with "only partially overlapping content," the team writes in the journal Nature Biology.

"It's like having the coordinates of all the cars in town, but no street map," Bernhard Palsson, a professor of bioengineering at the University of California San Diego Jacobs School of Engineering and one of the authors of the paper, said in a statement. "Without this tool, we don't know why people are moving the way they are."… Read more